(1) Nā mea maka

ʻO ka mea maka o ka HPMC hollow capsule ka mea i loaʻa mai ka fiber mea kanu maʻemaʻe (pine lāʻau), ka mea pili i ke kaiapuni, palekana a hilinaʻi.

Loaʻa ka gelatin hollow capsule mai ka collagen i nā ʻili holoholona a me nā iwi.I ke kaʻina hoʻoheheʻe, hoʻohui ʻia ka nui o nā mea kemika, kahi maʻalahi e hoʻolauna i nā pathogens o ka maʻi pipi pupule a me ka maʻi wāwae a me ka waha, etc.,.I nā makahiki i hala iho nei, ua hōʻike ʻia ka hanana "Poison Capsule" i nā pilikia he nui o nā capsules gelatin maʻamau, e like me ka "blue leather glue" i hōʻike ʻia e ka media, e hoʻonui ai i ka chromium i loko o ka capsule ma mua o ka maʻamau.

(2) Hoʻohana a me ka Paʻa Kemika

ʻO ka HPMC he cellulose derivative me ka inertness ikaika, ka hoʻohana ākea, nā waiwai kemika paʻa, ʻaʻohe hopena pili keʻa me nā lāʻau lapaʻau aldehyde, ʻaʻohe lohi disintegration.

Noho ʻo Lysine i ka gelatin, i ka wā e hoʻohana ai i ka gelatin i loko o ka capsule, e loaʻa kahi hanana lohi disintegration.E loaʻa i ka maʻi o ka lāʻau hōʻemi loa ka Maillard me ka gelatin (Browning Reaction).Inā loaʻa kahi lāʻau lapaʻau i loko o ka aldehyde, reductive sugar-based chemical, a i ʻole ka huaora C, a laila ʻaʻole kūpono ia no ka hoʻohana ʻana i ka capsule hollow gelatin.

(3) Waiwai

ʻO ka wai o ka gelatin hollow capsule ma kahi o 12.5% ​​a 17.5%.ʻO ka capsule gelatin me ka wai kiʻekiʻe o ka wai e hoʻopili i ka wai o ka lāʻau lapaʻau a i ʻole e komo i ka wai e kona hoʻopiha piha ʻana, e hoʻomaʻamaʻa a palupalu paha ka capsule, e pili ana i ka lāʻau i hoʻopiha ʻia.

ʻO ka wai o ka HPMC hollow capsule e pili ana i 3% a 9%, ʻaʻole ia e pane me ka hoʻopiha piha ʻana, a hiki ke mālama i nā waiwai kino maikaʻi e like me ka paʻakikī i ka wā e hoʻopiha ai i nā mea lāʻau o nā waiwai like ʻole, ʻoi aku ka kūpono no ka hygroscopicity a me ka hoʻopiha ʻana i ka wai. lāʻau paʻakikī.

(4) Ke koena mālama

ʻO ka mea nui o ka gelatin hollow capsule he protein, he mea maʻalahi ke hoʻohua i ka bacteria a me nā microorganism.Hiki ke waiho ʻia nā preservatives a me nā mea bacteriostatic i loko o ka capsule e pale ai i ka ulu ʻana o ka microbial i ka wā hana.Inā ʻoi aku ka nui o ka nui o ka nui, hiki ke hoʻonui ʻia ka waihona arsenic.I ka manawa like, pono e hoʻomaʻemaʻe ʻia nā capsule hollow gelatin e ka ethylene oxide ma hope o ka pau ʻana o ka hana ʻana, a aia ka chlorohydrin ma hope o ka sterilization ethylene oxide.ʻOiai ua pāpā ʻia nā koena Chlorohydrin mai ka hoʻohana ʻana.

ʻAʻole pono ka HPMC hollow capsules e hoʻohui i nā preservatives i ke kaʻina hana, ʻaʻole pono e sterilized, hiki ke hoʻokō piha i nā kūlana aupuni, a he mau capsule ʻōmaʻomaʻo olakino me ka ʻole o nā koena a me nā preservatives.

(5) Waihona

Loaʻa nā kūlana mālama ʻole o ka HPMC hollow capsules, ma kahi mahana o 10 a 30 ° C, a me kahi haʻahaʻa ma waena o 35% a me 65%, ʻaʻole e palupalu a paʻakikī a lilo i brittle.ʻO ka HPMC hollow capsule he friability o ≤ 2% ma kahi haʻahaʻa o 35% a me kahi hoʻololi capsule o ≤ 1% ma kahi mahana o 80 ° C;ʻAʻole pilikia ka mālama ʻana a me ka lawe ʻana i nā ʻāpana ʻāina āpau.

Hiki ke hoʻopili ʻia nā capsules gelatin ma lalo o nā kūlana haʻahaʻa kiʻekiʻe;ka paʻakikī a i ʻole ka friability ma lalo o nā kūlana haʻahaʻa haʻahaʻa, a hilinaʻi nui i ka mahana a me ka haʻahaʻa o ka wahi mālama.

(6) ʻO ke kaiapuni

Hoʻokō ʻia ka ʻili ʻana o ka HPMC hollow capsule maka e ka ʻili kino.Wehe ʻia ia mai ka lāʻau paina a ʻaʻole hoʻi i ka pilau.Hoʻemi nui ia i ka nui o ka wai i hoʻohana ʻia a hoʻemi i ka pollution kaiapuni.ʻAʻohe mea ʻino i hoʻohui ʻia i ka wā o ke kaʻina hana a ʻaʻohe haumia kaiapuni.

Hana ʻia nā capsules hollow gelatin me ka ʻili holoholona a me ka iwi ma ke ʻano he mea maka, i hoʻopili ʻia a fermented.Hoʻohui ka hana i ka nui o nā mea kemika, hana i kahi ʻala nui i ka wā o ka hana ʻana, a hoʻohana i ka nui o nā kumu wai.Hoʻopuka i ka haumia koʻikoʻi;He haʻahaʻa nō hoʻi ka hana hou ʻana o ka ʻōpala gelatin, a he nui nā kumu haumia i hana ʻia i ka wā e hoʻolei ʻia ai kāna ʻōpala.

(7) Hoʻokaʻawale i ka pilina me ka ea o waho

ʻO nā waiwai waiwai o ka HPMC hollow capsules e hoʻoholo e hiki iā ia ke hoʻokaʻawale pono i nā mea i waho o ka honua a pale i nā hopena ʻino me ka lewa, a ʻo kona ola ʻana he 24 mau mahina.

He manawa kūpono ka gelatin capsule ma kahi o 18 mau mahina, ʻoiai aia kekahi manawa mālama ma mua o ka hoʻohana ʻana e loaʻa i ka capsule ke ola pōkole, e pili pono ana i ke ola o ka lāʻau.

(8) Kāohi i ka ulu ʻana o ka maʻi bacteria

ʻO ka mea nui o ka HPMC hollow capsules he mea kanu ka fiber, ʻaʻole wale ia e hoʻonui i ka bacteria, akā keʻakeʻa pū hoʻi i ka ulu ʻana o ka bacteria.Ua hōʻike ʻia nā hoʻokolohua e hiki ke mālama ʻia nā capsule hollow HPMC i loko o ke kaiapuni ākea no ka manawa lōʻihi, a hiki ke mālama ʻia ka helu o nā microorganism ma lalo o ka pae maʻamau.

ʻO ka mea nui o ka gelatin hollow capsule he collagen, a ʻo ka collagen kahi moʻomeheu bacterial, e kōkua ana i ka maʻi bacteria e hoʻonui.Inā kūpono ʻole ka mālama ʻana, ʻoi aku ka nui o ka bacteria ma mua o ka maʻamau a e hoʻonui.

Hoʻopau.