I ka makahiki 1990, ua alakaʻi ʻo Pfizer i ka hoʻomohala ʻana a me ka papa inoa ʻana i ka huahana mua o ka honua non-gelatin capsule shell, ʻo ia ka mea nui o ka cellulose ester "hydroxypropyl methyl cellulose" mai nā mea kanu.No ka mea, ʻaʻole i loaʻa i kēia ʻano capsule hou nā mea holoholona, ​​mahalo ʻia e ka ʻoihana ma ke ʻano he "capsule kanu".I kēia manawa, ʻoiai ʻaʻole kiʻekiʻe ka nui o ke kūʻai aku ʻana o nā capsules mea kanu i ka mākeke capsule honua, ikaika loa kona ulu ʻana, me ka ulu ulu ʻana o ka mākeke.
　　
"Me ka hoʻomohala ʻana o ka ʻepekema lapaʻau a me ka ʻenehana a me nā ʻepekema pili, ua ʻike mālie ʻia ke koʻikoʻi o nā mea hoʻohana lāʻau lapaʻau i ka hana ʻana i nā hoʻomākaukau lāʻau lapaʻau, a ke piʻi nei ke kūlana o ka lāʻau lapaʻau."Ua kuhikuhi ʻo Ouyang Jingfeng, kahi mea noiʻi hui ma ka Chinese Academy of Chinese Medical Sciences, ʻaʻole i hoʻoholo wale nā ​​​​mea hoʻohana lāʻau lapaʻau i ka maikaʻi o nā ʻano hou a me nā hoʻomākaukau hou o nā lāʻau lapaʻau i kahi ākea nui, akā kōkua pū nō hoʻi i ka hoʻomākaukau ʻana e hana, hoʻopaʻa, solubilize. , hoʻonui i ka solubilize, hoʻonui i ka hoʻokuʻu, hoʻokuʻu hoʻomau, ka hoʻokuʻu ʻana, ka hoʻonohonoho ʻana, ka manawa, ka hoʻonohonoho ʻana, ka wikiwiki, ka maikaʻi a me ka lōʻihi o ka hana, a ma ke ʻano, hiki i ka hoʻomohala ʻana i kahi excipient hou maikaʻi loa ke alakaʻi i ka hoʻomohala ʻana i kahi papa nui. o nā ʻano dosage, hoʻomaikaʻi i ka maikaʻi o ka nui o nā lāʻau lapaʻau hou a me ka hoʻomākaukau ʻana, a ʻoi aku kona koʻikoʻi ma mua o ka hoʻomohala ʻana i kahi lāʻau hou.I loko o nā ʻano lāʻau lapaʻau e like me nā ʻaila cream, nā papa, nā injections, a me nā capsules, ua lilo nā capsules i mau ʻano kumu nui o ka hoʻomākaukau paʻa waha ma muli o ko lākou bioavailability kiʻekiʻe, hoʻomaikaʻi i ka kūpaʻa o nā lāʻau lapaʻau, a me ka hoʻonohonoho manawa a me ka hoʻokuʻu ʻana i nā lāʻau lapaʻau.

I kēia manawa, ʻo ka mea waiwai nui no ka hana ʻana i nā capsules he gelatin, ua hana ʻia ka gelatin e ka hydrolysis o nā iwi holoholona a me nā ʻili, a he macromolecule biological me kahi ʻano spiral ternary, me ka biocompatibility maikaʻi a me nā waiwai kino a me nā kemika.Eia nō naʻe, loaʻa i nā capsules gelatin kekahi mau palena i ka noi ʻana, a ʻo ka hoʻomohala ʻana i nā mea hou no nā pūpū capsule o nā kumu holoholona ʻole i lilo i wahi wela i ka noiʻi hou ʻana o nā excipients pharmaceutical.Ua ʻōlelo ʻo Wu Zhenghong, he kumu aʻoaʻo ma China Pharmaceutical University, ma muli o ka "maʻi pipi pupule" ma nā ʻāina ʻEulopa e like me Beretania, Palani a me Netherlands i nā makahiki 1990 (me Iapana ma Asia, kahi i loaʻa ai nā bipi hehena me ka maʻi pipi pupule) , ua hilinaʻi nui ka poʻe o nā ʻāina Komohana i ka pipi a me nā mea pili i ka pipi (ʻo ka gelatin kekahi o lākou).Eia kekahi, kū'ē nā Buddhist a me nā mea kanu i nā capsules gelatin i hanaʻia mai nā mea holoholona.Ma muli o kēia, ua hoʻomaka kekahi mau hui capsule haole e aʻo i nā mea hou no nā pūpū capsule o non-gelatin a me nā kumu holoholona ʻē aʻe, a ua hoʻomaka ka mana o nā capsules gelatin kuʻuna.

ʻO ka ʻimi ʻana i nā mea hou no ka hoʻomākaukau ʻana i nā capsules non-gelatin ʻo ia ke kuhikuhi o ka hoʻomohala ʻana i kēia manawa o nā excipients pharmaceutical.Ua kuhikuhi ʻo Ouyang Jingfeng i nā mea waiwai o nā capsules mea kanu i kēia manawa hydroxypropyl methylcellulose, starch i hoʻololi ʻia a me kekahi mau meaʻai hydrophilic polymer glues, e like me ka gelatin, carrageenan, xanthan gum a pēlā aku.ʻO ka hydroxypropyl methyl cellulose capsules i like ka solubility, disintegration a me ka bioavailability i nā capsules gelatin, ʻoiai ke loaʻa nei kekahi mau pono i loaʻa ʻole i nā capsules gelatin, akā ʻaʻole nui loa ka noi o kēia manawa, ma muli o ke kumukūʻai kiʻekiʻe o ka huahana, ke hoʻohālikelike ʻia me ka gelatin. ʻOi aku ka kiʻekiʻe o ka hydroxypropyl methyl cellulose capsule raw material cost, i ka hoʻohui ʻana i ka wikiwiki gel lohi, e hopena i kahi pōʻai hana lōʻihi.

I ka mākeke lāʻau lapaʻau honua, ʻo nā capsules mea kanu kekahi o nā huahana ulu wikiwiki loa.Ua ʻōlelo ʻo Wu Zhenghong e hoʻohālikelike ʻia me nā capsules gelatin, loaʻa i nā capsules mea kanu nā mea maikaʻi aʻe: ʻO ka mua, ʻaʻohe hopena crosslinking.Loaʻa i nā capsules mea kanu ka inertness ikaika a ʻaʻole maʻalahi ke hoʻopili ʻana me nā pūʻulu aldehyde a i ʻole nā ​​​​hui ʻē aʻe.He kūpono ka lua no nā lāʻau lapaʻau wai.ʻO ka maʻamau o nā capsules mea kanu e hoʻomalu mau ʻia ma waena o 5% a me 8%, a ʻaʻole maʻalahi ke hana kemika me nā mea i loko, a ʻo ka haʻahaʻa wai haʻahaʻa e hōʻoia i ka paʻa ʻana o nā mea hygroscopic i hiki ke maʻa.ʻO ke kolu ka hoʻohālikelike maikaʻi me nā mea hoʻohui lāʻau nui.Loaʻa i nā capsules meaʻai ke kūpono me ka lactose, dextrin, starch, microcrystalline cellulose, magnesium stearate a me nā mea hoʻohana lāʻau lapaʻau nui ʻē aʻe.ʻO ka hā o ka loaʻa ʻana o kahi hoʻopihapiha hoʻomaha hoʻomaha.Loaʻa i nā capsules mea kanu nā koi no ke kaiapuni hana o nā mea i hoʻopiha ʻia, inā ʻo ia nā koi no ke kaiapuni hana a i ʻole ka helu pass ma ka mīkini, hiki ke hōʻemi i ke kumukūʻai o ka hoʻohana.
　
　
"Ma ke ao nei, aia nā capsules mea kanu i ko lākou wā kamaliʻi, he kakaikahi wale nō nā ʻoihana e hiki ke hana i nā capsules lāʻau lāʻau kanu, a he mea pono e hoʻoikaika hou i ka noiʻi ʻana i nā kaʻina hana a me nā ʻano ʻē aʻe, me ka hoʻonui ʻana i nā hana hoʻolaha mākeke."Ua kuhikuhi ʻo Ouyang Jingfeng i kēia manawa, ua hōʻea ka huahana o nā capsules gelatin ma Kina i ka wahi mua ma ka honua, ʻoiai ka haʻahaʻa o ka mākeke o nā huahana capsule mea kanu.Eia kekahi, no ka mea, ʻaʻole i loli ke kaʻina hana o ka hana ʻana i nā capsules no hoʻokahi haneli mau makahiki, a ua hoʻolālā ʻia ka hoʻomaikaʻi mau ʻana o nā mea hana e like me ke kaʻina hana o ka gelatin, pehea e hoʻohana ai i ke kaʻina hana a me nā mea hana no ka hoʻomākaukau ʻana i nā capsules gelatin e hoʻomākaukau i ka mea kanu. Ua lilo nā capsules i mea koʻikoʻi o ka noiʻi, e pili ana i ka noiʻi kikoʻī o nā mea hana e like me ka viscosity, rheological properties a me ka viscoelasticity o nā mea.
　　

ʻOiai ʻaʻole hiki i nā capsules mea kanu ke hoʻololi i ka noho aliʻi ʻana o nā capsules hollow gelatin kuʻuna, ua ʻike ʻia nā mea hoʻokūkū o nā mea kanu i ka hoʻomākaukau ʻana i nā lāʻau lapaʻau Kina kuʻuna, nā hoʻomākaukau kūlohelohe a me nā meaʻai hana.Manaʻo ʻo Zhang Youde, he ʻenekinia kiʻekiʻe ma ke Kula o nā Materials Science and Engineering o Beijing Institute of Technology, me ka ʻike hohonu o ka poʻe i nā capsules mea kanu a me ka hoʻololi ʻana o ka manaʻo lāʻau lapaʻau o ka lehulehu, e ulu wikiwiki ana ka mākeke noi no nā capsules mea kanu.